Hydrochloric Acid → HCID 24759348, 화합물

HRID 598407노트

반응식

HRID 598407 반응식
[NH2:1][C:2]1[C:3]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([I:17])=[CH:13][C:12]=2[F:18])=[CH:4][C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[CH:19]1([S:22](Cl)(=[O:24])=[O:23])[CH2:21][CH2:20]1.Cl>N1C=CC=CC=1>[F:18][C:12]1[CH:13]=[C:14]([I:17])[CH:15]=[CH:16][C:11]=1[NH:10][C:3]1[C:2]([NH:1][S:22]([CH:19]2[CH2:21][CH2:20]2)(=[O:24])=[O:23])=[CH:7][N:6]([CH3:8])[C:5](=[O:9])[CH:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 2760919Cyclopropanesulfonyl chlorideHCID 58990848HCID 58990848, 화합물

생성물 1

HCID 24759348HCID 24759348, 화합물수율 79%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 5-amino-4-(2-fluoro-4-iodophenylamino)-1-methylpyridin-2(1H)-one (62.3 mg, 0.174 mmol) in dry pyridine (3 mL) at 0° C. (ice-salt bath), was added cyclopropanesulfonyl chloride (29 mg, 0.206 mmol). The resultant reaction mixture was allowed to warm to room temperature and stirred for 16 hours. Aqueous HCl (1N) (5 mL) was added and the mixture stirred for 15 minutes, resulting in the formation of a precipitate which was isolated by filtration, dried under vacuum, to afford the desired compound as a tan solid. (64 mg, 79% yield)

후처리

  1. customThe resultant reaction mixture
  2. stirringthe mixture stirred for 15 minutes
  3. customresulting in the formation of a precipitate which
  4. customwas isolated by filtration
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-7ee91f261ca74f35997615256b8b9a70
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897624B2

반응 노트

불러오는 중…