Sodium Hydroxide → 2-Piperidin-2-ylmethylbenzothiazole

HRID 598552노트

반응식

HRID 598552 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][N:12]1C(=O)C(F)(F)F.[OH-].[Na+]>CO>[NH:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH:11]1[CH2:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 231464011-(2-Benzothiazol-2-ylmethylpiperidin-1-yl)-2,2,2-trifluoroethanone

생성물 1

HCID 231463502-Piperidin-2-ylmethylbenzothiazole

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-(2-Benzothiazol-2-ylmethylpiperidin-1-yl)-2,2,2-trifluoroethanone, D29 (1.2 g) was dissolved in methanol (40 ml) and 2N sodium hydroxide solution (20 ml) and heated to 50° C. for 0.75 h. After cooling, the reaction solution was partitioned between dichloromethane and water. The organic solution was dried (MgSO4) and the solvent removed in vacuo. The residue was chromatographed (silica gel, 0-10% [9:1 MeOH/conc. ammonia solution] in dichloromethane) to afford the title compound (0.68 g).

후처리

  1. temperatureAfter cooling
  2. customthe reaction solution was partitioned between dichloromethane and water
  3. dry with materialThe organic solution was dried (MgSO4)
  4. customthe solvent removed in vacuo
  5. customThe residue was chromatographed (silica gel, 0-10% [9:1 MeOH/conc. ammonia solution] in dichloromethane)

출처 및 근거

ORD 기록
ord-390f30b0fe9c4e5b9a6ece84d55d2322
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897618B2

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