Methyl iodide → 5-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene

HRID 598720노트

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HRID 598720 반응식
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:16])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 574185474-tert-Butyl-2-methyl-6-nitro-phenol

생성물 1

HCID 213537455-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene수율 99%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
60 °C

실험 절차

4-tert-Butyl-2-methyl-6-nitro-phenol (209 mg, 1 mmol) was dissolved in 3 mL acetone. 552 mg K2CO3 (4 eq) was added, followed by addition of MeI (0.33 mL, 5 mmol). The reaction mixture was stirred vigorously at 60° C. overnight. After removal of the acetone, the residue was shaken with DCM. Filtration and evaporation of the solution yielded 221 mg product which was used as such.

후처리

  1. customAfter removal of the acetone
  2. stirringthe residue was shaken with DCM
  3. filtrationFiltration and evaporation of the solution

출처 및 근거

ORD 기록
ord-60b76187d62e4d6f8461cea5e16897e5
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897599B2

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