Chlorosuccinimide → 4-Amino-3-chloro-5-fluorobenzonitrile

HRID 59941

반응식

HRID 59941 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[F:10].C1C(=O)N([Cl:18])C(=O)C1>CC(O)=O>[NH2:1][C:2]1[C:3]([F:10])=[CH:4][C:5]([C:6]#[N:7])=[CH:8][C:9]=1[Cl:18]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 27564314-Amino-3-fluorobenzonitrile

생성물 1

HCID 680399954-Amino-3-chloro-5-fluorobenzonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
70 °C

실험 절차

A mixture of 4-amino-3-fluorobenzonitrile (184 mmol) and NCS (276 mmol) in AcOH (300 mL) was stirred at 70° C. for approximately 16 h. The mixture was concentrated. H2O was added to the residue and the solid product was filtered off and washed (sat. NaHCO3 and H2O). To eliminate H2O, THF was added and removed under reduced pressure to yield the desired product.

후처리

  1. concentrationThe mixture was concentrated
  2. additionH2O was added to the residue
  3. filtrationthe solid product was filtered off
  4. washwashed (sat. NaHCO3 and H2O)
  5. additionwas added
  6. customremoved under reduced pressure

출처 및 근거

ORD 기록
ord-306095c73a9a4bfabc97bcd9d3ba38ab
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440929B2

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