Sodium hydride → HCID 178498783, 화합물
반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][N:5]=[CH:4][C:3]=1[C:12]([O:14]C)=O.C(O)(=O)C.[CH:20](=[NH:22])[NH2:21].[H-].[Na+]>O1CCOCC1>[OH:14][C:12]1[C:3]2[CH:4]=[N:5][CH:6]=[C:7]([C:8]([O:10][CH3:11])=[O:9])[C:2]=2[N:21]=[CH:20][N:22]=1참가 물질
5
실험 절차
To the mixture of dimethyl 4-chloropyridine-3,5-dicarboxylate (0.6 g, 2.6 mmol) and formimidamide acetate (0.82 g, 7.8 mmol) in dioxane (20 mL) was added NaH (0.31 g, 7.8 mmol). The resulting mixture was refluxed for 48 hours, cooled to RT. The precipitate was filtered, and washed with EA to afford the title compound as grey solid (yield 56.1%).
후처리
- temperatureThe resulting mixture was refluxed for 48 hours
- filtrationThe precipitate was filtered
- washwashed with EA
출처 및 근거
- ORD 기록
- ord-d8e04bf101054bd485f02b6b7bb4af81
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09440968B2
반응 노트
불러오는 중…