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3-Fluorobenzoic Acid → 3-fluorobenzoic acid N'-{(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acryloyl}hydrazide

HRID 599553
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HRID 599553 반응식
C1C=CC2N(O)N=NC=2C=1.Cl.Cl.[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[CH:27]=[CH:28]/[C:29]([NH:31][NH2:32])=[O:30])[CH:18]=[CH:19][C:20]=1[N:21]1[CH:25]=[C:24]([CH3:26])[N:23]=[CH:22]1.[F:33][C:34]1[CH:35]=[C:36]([CH:40]=[CH:41][CH:42]=1)[C:37](O)=[O:38].C(N(C(C)C)CC)(C)C>CN(C=O)C.O.C(OCC)(=O)C.C(Cl)CCl>[CH3:13][O:14][C:15]1[CH:16]=[C:17](/[CH:27]=[CH:28]/[C:29]([NH:31][NH:32][C:37](=[O:38])[C:36]2[CH:40]=[CH:41][CH:42]=[C:34]([F:33])[CH:35]=2)=[O:30])[CH:18]=[CH:19][C:20]=1[N:21]1[CH:25]=[C:24]([CH3:26])[N:23]=[CH:22]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

9

반응물 4

HCID 99683-Fluorobenzoic AcidHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 66839298(E)-3-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]acrylic acid hydrazide dihydrochloride

생성물 1

HCID 670673443-fluorobenzoic acid N'-{(E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acryloyl}hydrazide수율 62.7%

시약·촉매·용매

4
HCID 111,2-Dichloroethane용매HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

HOBT (70 mg) and EDC (100 mg) were added to a solution of (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid hydrazide dihydrochloride (120 mg), 3-fluorobenzoic acid (49 mg) and IPEA (0.37 mL) in DMF, and the reaction solution was stirred at room temperature for 12 hours. Ethyl acetate and water were added to the reaction solution, and the precipitated solid was collected by filtration to obtain 86 mg of the title compound. The property value of the compound is as follows.

후처리

  1. filtrationthe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-048b9f0f77734a629f7d1e00d84d6888
출처 데이터셋
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07897632B2

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