Ethyl Acetate → 4-Fluoro-3-nitrobenzyl alcohol

HRID 599842노트

반응식

HRID 599842 반응식
[BH4-].[Na+].[F:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][C:5]=1[N+:12]([O-:14])=[O:13].C(OCC)(=O)C>CO.O>[F:3][C:4]1[CH:11]=[CH:10][C:7]([CH2:8][OH:9])=[CH:6][C:5]=1[N+:12]([O-:14])=[O:13]

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 5981294-Fluoro-3-nitrobenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 41675874-Fluoro-3-nitrobenzyl alcohol수율 103.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

Sodium borohydride (1.36 g, 35.95 mmol) was added to a solution of 4-fluoro-3-nitrobenzaldehyde (2.0 g, 11.83 mmol) in methanol (15 mL) and water (3.0 mL), and the mixture was stirred at room temperature for 3 hours. Water was then added to the reaction mixture, and extraction was performed with ethyl acetate. The organic extract was washed with saturated saline and dried over magnesium sulfate, and then concentrated under reduced pressure to yield the title compound (2.10 g, 95%) as a pale red oil.

후처리

  1. extractionThe organic extract
  2. washwas washed with saturated saline
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e1f1f5224c1e42da9c57b7e740b67605
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897792B2

반응 노트

불러오는 중…