Benzylamine → 1-Benzyl-3-(4-trifluoromethoxy-phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

HRID 599868

반응식

HRID 599868 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[F:23][C:24]([F:38])([F:37])[O:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]=[CH:33][N+]([O-])=O)=[CH:28][CH:27]=1>C(Cl)Cl>[CH2:15]([N:22]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:13][C:12]=2[C:32]([C:29]2[CH:28]=[CH:27][C:26]([O:25][C:24]([F:23])([F:37])[F:38])=[CH:31][CH:30]=2)=[CH:33]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 7504BenzylamineHCID 6882334-Trifluoromethoxy-(2-nitro-vinyl)-benzeneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

생성물 1

HCID 114629001-Benzyl-3-(4-trifluoromethoxy-phenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound (0.28 g) was prepared from 0.50 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 274 μL of benzylamine, and 0.59 g of 1-trifluoromethoxy-4-(2-nitro-vinyl)-benzene using CH2Cl2 as the solvent. MS (ESI): exact mass calculated for C21H19F3N2O, 372.14. found, m/z 373.2 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.44-7.41 (m, 2H), 7.37-7.26 (m, 5H), 7.19-7.17 (m, 3H), 5.15 (s, 2H), 4.37 (s, 2H), 3.51 (t, J=6.3 Hz, 2H), 2.87 (t, J=6.3 Hz, 2H).

출처 및 근거

ORD 기록
ord-f19a1f98b2404abf818e986dcd2ad444
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897771B2

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