Sodium Hydroxide → (4-Nitropyridin-2-yl)methanol

HRID 600263노트

반응식

HRID 600263 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:10][O:11]C(=O)C)[CH:5]=1)([O-:3])=[O:2].[OH-].[Na+]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([CH2:10][OH:11])[CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14761430(4-Nitropyridin-2-yl)methyl acetate

생성물 1

HCID 14761455(4-Nitropyridin-2-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of acetic acid 4-nitro-pyridin-2-ylmethyl ester (16)(0.49 g, 2.5 mmol) in methanol (5 mL), was added a solution of sodium hydroxide (2N, 1.6 mL) and the reaction was stirred for 30 minutes and then concentrated in vacuo. The residue was diluted with water (10 mL) and extracted with ethyl acetate (2×10 mL). The combined extracts were washed with brine (10 mL) and concentrated in vacuo to afford a crude oil which solidified upon standing. Single peak in LC-MS analysis, (0.13 g 33%); m/z (LC-MS, ESP), RT=2.67 mins, (M+H) 155.

후처리

  1. concentrationconcentrated in vacuo
  2. additionThe residue was diluted with water (10 mL)
  3. extractionextracted with ethyl acetate (2×10 mL)
  4. washThe combined extracts were washed with brine (10 mL)
  5. concentrationconcentrated in vacuo
  6. customto afford a crude oil which

출처 및 근거

ORD 기록
ord-5b7dff31fb944675a071fa21c386ddaf
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902193B2

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