Water → 5-Iodo-2-(methylthio)benzonitrile
반응식
[CH3:1][S-:2].[Na+].F[C:5]1[CH:12]=[CH:11][C:10]([I:13])=[CH:9][C:6]=1[C:7]#[N:8].O>CS(C)=O>[I:13][C:10]1[CH:11]=[CH:12][C:5]([S:2][CH3:1])=[C:6]([CH:9]=1)[C:7]#[N:8]참가 물질
5
실험 절차
Sodium thiomethoxide (0.142 g) was added to a solution of 2-fluoro-5-iodobenzonitrile (0.5 g) in DMSO (1 mL) and the mixture stirred. An exotherm was noted. After stirring for 90 min, water was added and the solid that precipitated was collected, washed with water and dried at 50° C. under vacuum to leave the subtitle compound as an off-white solid (0.52 g).
후처리
- stirringAfter stirring for 90 min
- customthe solid that precipitated
- customwas collected
- washwashed with water
- customdried at 50° C. under vacuum
출처 및 근거
- ORD 기록
- ord-5a4a1bb640f549d697a5ac4e26dfa675
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07902181B2
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