참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Benzoxazolinone, 5-bromo- | HCID 26853 | — |
| 반응물 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 5-Bromo-3-(2-methoxyethyl)benzo[d]oxazol-2(3H)-one | HCID 57999690 | — |
반응 단계
A mixture of 5-bromobenzo[d]oxazol-2(3H)-one (2.06 g), 1-bromo-2-methoxyethane (1.085 mL) and potassium carbonate (3.99 g) in acetonitrile (15 mL) was heated at 60° C. for 16 h. Water was added and the mixture was extracted with ethyl acetate (3 times). The organic layers were dried over magnesium sulfate, evaporated and purified by flash silica chromatography eluting with 5:1 isohexane/acetone to give the subtitle compound (1.359 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07902181B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_03 |
|---|
| ORD ID | ord-f266f099fe2b4d08929103f9150f70a2 |
|---|
| 출처 메모 | uspto-grants-2011_03 |
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