Hydrochloric Acid → N-Hydroxy-6-methoxy-3-pyridinecarboximidoyl chloride

HRID 600717노트

반응식

HRID 600717 반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[N:10][OH:11])=[CH:5][CH:4]=1.C(=O)(O)[O-].[Na+].[ClH:17]>O>[OH:11][N:10]=[C:9]([Cl:17])[C:6]1[CH:7]=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 765644496-Methoxy-pyridine-3-carboxaldehyde oxime

생성물 1

HCID 76564447N-Hydroxy-6-methoxy-3-pyridinecarboximidoyl chloride

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

To oxime 1c (1.25 g; 8.18 mmol) in concentrated hydrochloric acid (6.0 mL) at 0° C., was added dropwise bleach (9 mL). The reaction mixture was stirred at 0° C. for 1 h, diluted with water (20 mL) and brought to about pH=3 with saturated sodium bicarbonate. The resulting solid was collected, washed with water and dried. 2c was isolated as a white solid.

후처리

  1. customThe resulting solid was collected
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-924c994f1adb459a87e50d9072904c94
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902227B2

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