Isobutyraldehyde → HCID 136374159, 화합물

HRID 601217노트

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HRID 601217 반응식
[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2[NH:14][C:13]3[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=3[S:11](=[O:20])(=[O:19])[N:10]=2)=[C:5]([OH:21])[C:4]2[S:22][CH:23]=[CH:24][C:3]1=2.[CH3:25][CH:26]([CH3:29])[CH:27]=O>CN(C)C(=O)C>[O:19]=[S:11]1(=[O:20])[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[NH:14][C:9]([C:6]2[C:7](=[O:8])[N:2]([N:1]=[CH:25][CH:26]([CH3:29])[CH3:27])[C:3]3[CH:24]=[CH:23][S:22][C:4]=3[C:5]=2[OH:21])=[N:10]1

참가 물질

4

반응물 2

HCID 6561IsobutyraldehydeHCID 1363736274-amino-6-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-7-hydroxythieno[3,2-b]pyridin-5(4H)-one

생성물 1

HCID 136374159HCID 136374159, 화합물수율 65%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

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온도
25 °C

실험 절차

The product of Example 268D (0.10 g, 0.27 mmol) was reacted with 2-methyl-propionaldehyde (0.20 g, 2.77 mmol) in N,N-dimethylacetamide (3 mL) in a sealed tube at 135° C. for 40 minutes in a microwave reactor. The reaction was cooled to 25° C. and concentrated under vacuum. The resulting residue was triturated with a mixture of 25% ethyl acetate in hexanes and filtered to give the title compound as a solid (0.073 g, 65%). MS (APCI+) m/z 417 (M+H)+.

후처리

  1. concentrationconcentrated under vacuum
  2. customThe resulting residue was triturated with a mixture of 25% ethyl acetate in hexanes
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-86834cd6a7e149619afe1339e89261ec
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902203B2

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