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Ammonium formate → HCID 136358401, 화합물

HRID 601305
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HRID 601305 반응식
C([O:8][C:9]1[CH:37]=[CH:36][C:12]2[NH:13][C:14]([C:19]3[C:20](=[O:35])[N:21]([NH:30][CH2:31][CH:32]4[CH2:34][CH2:33]4)[C:22]4[C:27]([C:28]=3[OH:29])=[CH:26][CH:25]=[CH:24][CH:23]=4)=[N:15][S:16](=[O:18])(=[O:17])[C:11]=2[CH:10]=1)C1C=CC=CC=1.C([O-])=O.[NH4+]>O1CCCC1.[Pd].[OH-].[OH-].[Pd+2]>[CH:32]1([CH2:31][NH:30][N:21]2[C:22]3[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:28]([OH:29])=[C:19]([C:14]3[NH:13][C:12]4[CH:36]=[CH:37][C:9]([OH:8])=[CH:10][C:11]=4[S:16](=[O:17])(=[O:18])[N:15]=3)[C:20]2=[O:35])[CH2:33][CH2:34]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 2723923Ammonium formateHCID 1363584023-[7-(benzyloxy)-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl]-1-[(cyclopropylmethyl)amino]-4-hydroxyquinolin-2(1H)-one

생성물 1

HCID 136358401HCID 136358401, 화합물수율 53%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 9942167Palladium hydroxide촉매
HCID 8028
Tetrahydrofuran
용매

실험 절차

The product of Example 320B (0.296 g, 0.57 mmol) in tetrahyrofuran (15 mL) was reacted with a catalytic amount of palladium hydroxide on carbon, a catalytic amount of 5% palladium on carbon, and ammonium formate (0.180 g, 2.85 mmol) at 60° C. for 2 hours. The warm reaction mixture was filtered through celite® (diatomaceous earth) and the filtrate was diluted with diethyl ether and the precipitate filtered and dried to give the title compound (0.127 g, 53%).

후처리

  1. customThe warm reaction mixture
  2. filtrationwas filtered through celite® (diatomaceous earth)
  3. additionthe filtrate was diluted with diethyl ether
  4. filtrationthe precipitate filtered
  5. customdried

출처 및 근거

ORD 기록
ord-bb9973160b93467ba0e49d2aebe1d180
출처 데이터셋
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07902203B2

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