Hydrochloric Acid → 2-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid

HRID 60142노트

반응식

HRID 60142 반응식
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([O-:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1.[Na+]>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:20]=[C:12]3[CH2:13][CH:14]([C:17]([OH:19])=[O:18])[CH2:15][CH2:16][N:11]3[N:10]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 117776381Sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate

생성물 1

HCID 839653482-(4-Fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid수율 40.1%

실험 절차

Concentrated hydrochloric acid (0.16 ml) was added to an aqueous solution (2 ml) of the sodium 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate (530 mg) obtained in (Example 5.2) <Step 2>, and the obtained mixture was then stirred for 15 minutes. Thereafter, the precipitated solid was collected by filtration, so as to obtain the title compound (196 mg) in the form of a whitish brown solid.

후처리

  1. customobtained in (Example 5.2) <Step 2>
  2. filtrationThereafter, the precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-7b7af2c4c64f4917a04b13dfb4b6fb49
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440970B2

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