Potassium Carbonate → HCID 67059839, 화합물

HRID 601458노트

반응식

HRID 601458 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH2:17][CH:18]([CH2:20][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])[CH3:19]>CC(C)=O>[CH3:19][C@@H:18]([CH2:20][CH2:21][CH:22]=[C:23]([CH3:25])[CH3:24])[CH2:17][CH2:16][O:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 130194-CyanophenolHCID 43282458-Bromo-2,6-dimethyloct-2-ene

생성물 1

HCID 67059839HCID 67059839, 화합물수율 91.4%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4-cyanophenol (6.0 g, 50.0 mmol), potassium carbonate (27.6 g, 200 mmol) and citronellylbromide (13.15 g, 60.0 mmol) in acetone (200 mL) was heated under reflux for 24 hours. The solvent was evaporated and the residue was taken up with CH2Cl2 (60 mL×2) and the solution filtered. The solvent was evaporated and the resulting oil was purified by flash column chromatography over silica gel (EtOAc/hexanes 1:1) as eluant to give 4-[(3S)-3,7-dimethyl-6-octenyloxy]cyanobenzene (11.76 g, 45.7 mmol, 91.4% yield) as a white oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hours
  3. customThe solvent was evaporated
  4. filtrationthe solution filtered
  5. customThe solvent was evaporated
  6. customthe resulting oil was purified by flash column chromatography over silica gel (EtOAc/hexanes 1:1) as eluant

출처 및 근거

ORD 기록
ord-67f4c1c99a004d5c846fb66a11ed4185
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902363B2

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