Methyl iodide → 1-(4-Fluoro-3-methanesulfonyl-phenyl)-propan-2-one

HRID 601616노트

반응식

HRID 601616 반응식
[Na+].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[O:12])[CH3:11])=[CH:5][C:4]=1[S:13]([O-:15])=[O:14].[CH3:16]I>CN(C=O)C>[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[O:12])[CH3:11])=[CH:5][C:4]=1[S:13]([CH3:16])(=[O:15])=[O:14]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 671597242-Fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt

생성물 1

HCID 574668151-(4-Fluoro-3-methanesulfonyl-phenyl)-propan-2-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution comprising 2-fluoro-5-(2-oxo-propyl)-benzenesulfinic acid sodium salt (AG2) (15.43 g, 64.83 mmol) in DMF (300 ml) is treated with methyl iodide (18.45 g, 130 mmol). The reaction mixture is stirred at room temperature for 30 minutes. Purification is carried out by chromatography on silica (eluting with 4:1 hexane-ethyl acetate) to afford the titled compound.

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-f261ee5e44774a379824232bcd7ff4dd
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902375B2

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