Dimethylformamide → HCID 59180081, 화합물

HRID 601941노트

반응식

HRID 601941 반응식
[CH:1]12[CH2:6][CH:5]1[CH2:4][C:3](=O)[CH2:2]2.O=P(Cl)(Cl)[Cl:10].CN([CH:16]=[O:17])C>C(Cl)Cl>[Cl:10][C:3]1[CH2:4][C@H:5]2[C@H:1]([CH2:6]2)[C:2]=1[CH:16]=[O:17]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 549318Bicyclo[3.1.0]hexan-3-one

생성물 1

HCID 59180081HCID 59180081, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Bicyclo[3.1.0]hexan-3-one (192 mg, 2.0 mmol) was reacted with POCl3, (0.33 mL, 3.6 mmol) and dry DMF (0.31 mL, 4.0 mmol) in dry CH2Cl2 (0.3 mL) according to General Procedure 1.1.A. The material was purified by passing through a pad of silica gel eluting with Et2O to afford the title compound. The material was used as is in the next step.

후처리

  1. customThe material was purified

출처 및 근거

ORD 기록
ord-4974b6cf61274c90b4a21cf112040461
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902252B2

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