Tetrahydrofuran → N-(2-methylcyclopentyl)-3,4-difluorobenzamide

HRID 602000

반응식

HRID 602000 반응식
C1COCC1.[F:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[F:16])[C:10](Cl)=[O:11].Cl.[CH3:18][CH:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[NH2:24].C(N(CC)CC)C>C(OCC)(=O)C>[CH3:18][CH:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[NH:24][C:10](=[O:11])[C:9]1[CH:13]=[CH:14][C:15]([F:16])=[C:7]([F:6])[CH:8]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 27245193,4-Difluorobenzoyl chlorideHCID 191014392-Methylcyclopentan-1-amine hydrochloride

생성물 1

HCID 57445707N-(2-methylcyclopentyl)-3,4-difluorobenzamide수율 84.3%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a mixture of 10 ml of THF and 0.60 g of 3,4-difluorobenzoyl chloride were added 0.37 g of 2-methylcyclopentylamine hydrochloride and 1.0 g of triethylamine, and the mixture obtained was stirred at room temperature for 3 hours. Then, ethyl acetate was added to the reaction mixture and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.55 g of N-(2-methylcyclopentyl)-3,4-difluorobenzamide.

후처리

  1. customthe mixture obtained
  2. filtrationfiltered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8ab286347c77495d9716b68571a0fd09
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902400B2

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