반응식
CC1C=CC(C)N1C(C1C=[CH:12][C:13]([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][C:23](=[O:37])[C:24]3[CH:29]=[CH:28][C:27]([C:30]4[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[CH:31]=4)=[N:26][CH:25]=3)[CH2:18][CH2:17]2)=[N:14]C=1)=O.[N:38]1[CH:43]=[CH:42]C=C(N2CCC(N)CC2)N=1>>[F:36][C:32]1[CH:31]=[C:30]([C:27]2[CH:28]=[CH:29][C:24]([C:23]([NH:22][CH:19]3[CH2:18][CH2:17][N:16]([C:13]4[N:14]=[N:38][CH:43]=[CH:42][CH:12]=4)[CH2:21][CH2:20]3)=[O:37])=[CH:25][N:26]=2)[CH:35]=[CH:34][CH:33]=1참가 물질
3
실험 절차
6-(3-fluorophenyl)-N-(1-pyridazin-3-ylpiperidin-4-yl)nicotinamide was prepared analogous to N-(1-{5-[(2,5-dimethyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]pyridin-2-yl}piperidin-4-yl)-6-(3-fluorophenyl)nicotinamide, except 1-(pyridazin-3-yl)piperidin-4-amine was used as R—NH2. M+H=378.3 observed, 378.17 expected.
출처 및 근거
- ORD 기록
- ord-0e4212f700554afa853a4788c06354d7
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07902373B2
연결된 노트
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