1-Benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine → 3-[2-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine

HRID 602196노트

반응식

HRID 602196 반응식
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH:17]=[CH:18][C:19]2[S:23][C:22]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)=[N:21][C:20]=2[CH3:31])[CH2:12]1)=O)C1C=CC=CC=1>Cl>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([C:22]2[S:23][C:19]([CH:18]=[CH:17][CH:13]3[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]3)=[C:20]([CH3:31])[N:21]=2)=[CH:25][CH:26]=1

참가 물질

3

반응물 1

HCID 672674511-Benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine

생성물 1

HCID 672670783-[2-[2-(4-Chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine수율 92%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

1-Benzyloxycarbonyl-3-[2-[2-(4-chlorophenyl)-4-methylthiazol-5-yl]ethenyl]piperidine (1.16 g, 2.56 mmol) in 6 mol/L hydrochloric acid (25 mL) was stirred for 1 hour while being refluxed. Subsequently, the reaction mixture washed with ethyl acetate. A 10 mol/L aqueous sodium hydroxide solution was then added to make the mixture basic and the mixture was extracted with ethyl acetate. The extract washed with brine, followed by drying over magnesium sulfate and evaporation of the solvent. The residue was air-dried to give 749 mg (92%) of the desired compound as a yellow powder.

후처리

  1. temperaturewhile being refluxed
  2. washSubsequently, the reaction mixture washed with ethyl acetate
  3. additionA 10 mol/L aqueous sodium hydroxide solution was then added
  4. extractionthe mixture was extracted with ethyl acetate
  5. washThe extract washed with brine
  6. dry with materialby drying over magnesium sulfate and evaporation of the solvent
  7. customThe residue was air-dried

출처 및 근거

ORD 기록
ord-27b844eb270344d99ae76514f6bcf323
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07902367B2

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