tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate → (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride

HRID 602343노트

반응식

HRID 602343 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C@H:11]2[CH2:15][CH2:14][CH2:13][N:12]2C(OC(C)(C)C)=O)=[O:10])=[CH:4][CH:3]=1>Cl.O1CCOCC1>[Cl-:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C@H:11]2[CH2:15][CH2:14][CH2:13][NH2+:12]2)=[O:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 9138711tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate

생성물 1

HCID 86607080(R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

4.00 g (12.3 mmol) of tert-butyl (R)-2-(4-chlorophenylcarbamoyl)pyrrolidine-1-carboxylate are dissolved in 20 ml of 4N HCl in dioxane and left at room temperature for 2 hours. The reaction mixture is evaporated and dried, giving (R)-2-(4-chlorophenylcarbamoyl)pyrrolidinium chloride as a slightly brownish solid; ESI 225.

후처리

  1. customThe reaction mixture is evaporated
  2. customdried

출처 및 근거

ORD 기록
ord-d2ff1e1cad3a49b6b083bc46af3bb1f2
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906516B2

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