Ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate → 4-(3-Oxomorpholin-4-yl)phenylacetic acid

HRID 602347노트

반응식

HRID 602347 반응식
[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1>[OH-].[Na+].C(O)C>[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:12][CH:13]=1

참가 물질

4

반응물 1

HCID 58691263Ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate

생성물 1

HCID 586912414-(3-Oxomorpholin-4-yl)phenylacetic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

20.2 g (76.8 mmol) of ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate are dissolved in a solution of 3.37 g of sodium hydroxide in 40 ml of ethanol, and the reaction solution is stirred at room temperature for 18 hours. The reaction mixture is evaporated, and the residue is dissolved in water and acidified to a pH of 3 using 1N hydrochloric acid. The mixture is extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and evaporated, giving 4-(3-oxomorpholin-4-yl)phenylacetic acid as a yellowish solid; ESI 236.

후처리

  1. customThe reaction mixture is evaporated
  2. dissolutionthe residue is dissolved in water
  3. extractionThe mixture is extracted with ethyl acetate
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-170d3c7a97ec4276bbece135aae11fd5
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906516B2

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