Sodium Hydroxide → 2-(4-Fluorophenyl)pyridine-4-carboxylic acid

HRID 602382노트

반응식

HRID 602382 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][N:17]=2)[C:11]([O:13]C)=[O:12])=[CH:4][CH:3]=1.[OH-].[Na+]>CO.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:15]=[CH:16][N:17]=2)[C:11]([OH:13])=[O:12])=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 66732391Methyl 2-(4-fluorophenyl)pyridine-4-carboxylate

생성물 1

HCID 463131162-(4-Fluorophenyl)pyridine-4-carboxylic acid수율 51.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl 2-(4-fluorophenyl)isonicotinate (278 mg, 1.20 mmol) was dissolved in methanol (2 mL) and the solution was added with 2 mol/L aqueous sodium hydroxide solution (2 mL, 4.0 mmol), followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure and the obtained reaction mixture was dissolved in water. The solution was washed with ethyl acetate, then was added with 1 mol/L hydrochloric acid, and the obtained crystal was collected by filtration to obtain 2-(4-fluorophenyl)isonicotinic acid (134 mg, 51%).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained reaction mixture
  3. washThe solution was washed with ethyl acetate
  4. additionwas added with 1 mol/L hydrochloric acid
  5. filtrationthe obtained crystal was collected by filtration

출처 및 근거

ORD 기록
ord-16046aadcd824ba8aa7e7e0bcaf64c8d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906522B2

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