Pyrrolidine → 4-Nitro-2-(pyrrolidin-1-yl)pyridine

HRID 602384

반응식

HRID 602384 반응식
Cl[C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1COCC1>[N+:8]([C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:7]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 7351522-Chloro-4-nitropyridine

생성물 1

HCID 534859644-Nitro-2-(pyrrolidin-1-yl)pyridine수율 24%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

2-Chloro-4-nitropyridine (2.0 g, 12.2 mmol) was dissolved in THF (30 mL) and the solution was added with pyrrolidine (3.25 mL, 38.9 mmol), followed by stirring at 80° C. overnight. After an insoluble matter of the reaction mixture was filtered off, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80) to obtain 4-nitro-2-(pyrrolidin-1-yl)pyridine (560 mg, 24%).

후처리

  1. filtrationAfter an insoluble matter of the reaction mixture was filtered off
  2. customthe solvent was evaporated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80)

출처 및 근거

ORD 기록
ord-eecdad9079164c198f941dc04bb20403
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906522B2

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