Morpholine → Morpholine-4-carboxamide

HRID 602427

반응식

HRID 602427 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C[Si]([N:11]=[C:12]=[O:13])(C)C>C(O)(C)C>[N:1]1([C:12]([NH2:11])=[O:13])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 70696Trimethylsilyl isocyanate

생성물 1

HCID 75088Morpholine-4-carboxamide수율 102.4%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a stirred solution of morpholine (1.3 mL, 15 mmol) in isopropanol (30 mL) at rt was added trimethylsilylisocyanate (2.8 mL, 21 mmol) and the resulting solution stirred overnight before the volatiles were removed in vacuo to give morpholine-4-carboxylic acid amide (2.0 g, quant.) as a solid; 1H-NMR (300 MHz, d6-DMSO) 6.00 (2H, s), 3.51-3.54 (4H, s), 3.23-3.26 (4H, s).

후처리

  1. customwere removed in vacuo

출처 및 근거

ORD 기록
ord-72b796d8e7204dd599c7a71d3fddf1fd
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906533B2

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