N-bromobutanimide → 3-bromo-5-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridine

HRID 602535노트

반응식

HRID 602535 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[C:11]1[CH:12]=[C:13]2[CH:19]=[CH:18][N:17]([C:20]3[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=3)[C:14]2=[CH:15][N:16]=1)[CH3:2].C1C(=O)N([Br:36])C(=O)C1>C(Cl)Cl>[Br:36][C:19]1[C:13]2[C:14](=[CH:15][N:16]=[C:11]([C:4]3[C:5]([CH2:9][CH3:10])=[CH:6][CH:7]=[CH:8][C:3]=3[CH2:1][CH3:2])[CH:12]=2)[N:17]([C:20]2[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=2)[CH:18]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 582699455-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridine

생성물 1

HCID 671527283-bromo-5-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 5-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridine (2.36 g, 6.4 mmol) in DCM (50 mL), NBS (1.25 g, 7.0 mmol) is added and the mixture is stirred at room temperature for 1 h. The mixture is concentrated under reduced pressure, and the product is dissolved in a 5:1 EtOAc/Hexane mixture and filtered over a small pad of silica gel. The solvent is removed under reduced pressure to afford 3-bromo-5-(2,6-diethyl-phenyl)-1-(4-isopropyl-phenyl)-1H-pyrrolo[2,3-c]pyridine.

후처리

  1. concentrationThe mixture is concentrated under reduced pressure
  2. dissolutionthe product is dissolved in a 5:1 EtOAc/Hexane mixture
  3. filtrationfiltered over a small pad of silica gel
  4. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-ef0192e6236d439aba8bb7f2b6883503
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906528B2

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