Potassium Carbonate → HCID 62804946, 화합물

HRID 602794노트

반응식

HRID 602794 반응식
[Br:1][C:2]1[CH:3]=[C:4]([SH:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][C:11]([O:13][CH3:14])=[O:12].C(=O)([O-])[O-].[K+].[K+].[NH4+].[Cl-]>C(OCC)C>[CH3:14][O:13][C:11](=[O:12])[CH2:10][S:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 25517Ammonium ChlorideHCID 60984Methyl bromoacetateHCID 80597m-Bromobenzenethiol

생성물 1

HCID 62804946HCID 62804946, 화합물수율 110.3%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 8.0 g (42 mmol) of 3-bromothiophenol was treated with 7.1 g (47 mmol) of methyl bromoacetate and potassium carbonate. The resulting suspension was stirred at reflux for 24 hrs, cooled to RT and neutralized with a saturated aqueous solution of NH4Cl. Diethylether was added, the phases were separated and the aqueous one was extracted twice with diethylether. The combined organic phases were dried over Na2SO4, filtered and evaporated to give 12.1 g (99%) of (3-bromo-phenylsulfanyl)-acetic acid methyl ester as a light yellow oil, MS: 279 (MNH4+, 1Br).

후처리

  1. temperatureat reflux for 24 hrs
  2. customthe phases were separated
  3. extractionthe aqueous one was extracted twice with diethylether
  4. dry with materialThe combined organic phases were dried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-32dcfe7c405c47f483fa96bed84642ae
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906546B2

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