Pyridine → 2,2,2-trichloro-N-[3-chloro-4-(trifluoromethyl)phenyl]acetamide
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[C:4]([Cl:12])[CH:3]=1.N1C=CC=CC=1.[Cl:19][C:20]([Cl:25])([Cl:24])[C:21](Cl)=[O:22]>ClCCl>[Cl:19][C:20]([Cl:25])([Cl:24])[C:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[C:4]([Cl:12])[CH:3]=1)=[O:22]참가 물질
5
실험 절차
To a solution of 4-amino-2-chlorobenzotrifluoride (300 mg) and pyridine (243 mg) in dichloromethane (10 mL) was added a solution of trichloroacetyl chloride (279 mg) in dichloromethane (5 mL) dropwise. The solution was stirred for 2 hrs and then concentrated at reduced pressure. The residue was purified by silica gel chromatography eluting with 0-10% ethyl acetate in hexane to give the title compound as a white solid (360 mg, 69%).
후처리
- concentrationconcentrated at reduced pressure
- customThe residue was purified by silica gel chromatography
- washeluting with 0-10% ethyl acetate in hexane
출처 및 근거
- ORD 기록
- ord-ada302043cf441feab5994ff6e306249
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07906645B2
반응 노트
불러오는 중…