Hydrochloric Acid → 1-[(1-Benzylpiperidin-3-yl)methyl]piperazin-2-one dihydrochloride

HRID 603179노트

반응식

HRID 603179 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][C:16]2=[O:28])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>ClCCl.O1CCOCC1>[ClH:29].[ClH:29].[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][N:15]2[CH2:20][CH2:19][NH:18][CH2:17][C:16]2=[O:28])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57656824Tert-butyl 4-[(1-benzylpiperidin-3-yl)methyl]-3-oxopiperazine-1-carboxylate

생성물 1

HCID 672206771-[(1-Benzylpiperidin-3-yl)methyl]piperazin-2-one dihydrochloride수율 100%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of tert-butyl 4-[(1-benzylpiperidin-3-yl)methyl]-3-oxopiperazine-1-carboxylate (95 mg) in dichloromethane (1 mL) was added 4M hydrochloric acid in dioxane (1 mL). The mixture was stirred at room temperature for 15 minutes and then evaporated to give the title compound as a sticky white solid (89 mg, 100%).

후처리

  1. customevaporated

출처 및 근거

ORD 기록
ord-0e2b7747ec7a4b0f88a1e5c05f460ca3
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906645B2

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