Propargyl bromide → (2R)-1-(tert-Butoxycarbonyl)-4-(2-methylprop-2-en-1-yl)piperazine-2-carboxylic acid

HRID 603251노트

반응식

HRID 603251 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]#[CH:16])[CH2:10][C@@H:9]1[C:17]([OH:19])=[O:18])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:20](OC(N1CCN(C(C)C)C[C@@H]1C(O)=O)=O)(C)(C)C.C(Br)C#C>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([CH3:20])=[CH2:16])[CH2:10][C@@H:9]1[C:17]([OH:19])=[O:18])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 7842Propargyl bromideHCID 51440433(2R)-1-(tert-butoxycarbonyl)-4-isopropylpiperazine-2-carboxylic acidHCID 57656800(2R)-1-(tert-Butoxycarbonyl)-4-(prop-2-yn-1-yl)piperazine-2-carboxylic acid

생성물 1

HCID 59846065(2R)-1-(tert-Butoxycarbonyl)-4-(2-methylprop-2-en-1-yl)piperazine-2-carboxylic acid

실험 절차

(2R)-1-(tert-Butoxycarbonyl)-4-(prop-2-yn-1-yl)piperazine-2-carboxylic acid used in Route E1 was prepared using the procedure described for (2R)-1-(tert-butoxycarbonyl)-4-isopropylpiperazine-2-carboxylic acid above but using prop-2-ynyl bromide.

후처리

  1. customwas prepared

출처 및 근거

ORD 기록
ord-7a9ac3dbc7fa4fb593a3def31ed1cc01
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906645B2

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