Pyridine → N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide

HRID 60380

반응식

HRID 60380 반응식
[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.N1C=CC=CC=1>O>[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 885792-Pyridinamine, 5-iodo-

생성물 1

HCID 21772024N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide수율 86.2%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 5-iodopyridin-2-amine (25.5 g), 4-methylbenzene-1-sulfonyl chloride (23.2 g) and pyridine (250 mL) was stirred at 100° C. overnight. The reaction mixture was poured into water (1.2 L) and stirred. The resulting solid was collected by filtration. The obtained solid was washed with water and diethyl ether and dried in vacuo to give the title compound (37.4 g) as a white solid.

후처리

  1. stirringstirred
  2. filtrationThe resulting solid was collected by filtration
  3. washThe obtained solid was washed with water and diethyl ether
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-2f3fa683d20e43d580c697040c92e7b9
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440987B2

연결된 노트

불러오는 중…