Pyridine → N-(5-Iodo-pyridin-2-YL)-4-methyl-benzenesulfonamide
반응식
[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.N1C=CC=CC=1>O>[I:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:16]([C:13]2[CH:14]=[CH:15][C:10]([CH3:9])=[CH:11][CH:12]=2)(=[O:18])=[O:17])=[N:6][CH:7]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 5-iodopyridin-2-amine (25.5 g), 4-methylbenzene-1-sulfonyl chloride (23.2 g) and pyridine (250 mL) was stirred at 100° C. overnight. The reaction mixture was poured into water (1.2 L) and stirred. The resulting solid was collected by filtration. The obtained solid was washed with water and diethyl ether and dried in vacuo to give the title compound (37.4 g) as a white solid.
후처리
- stirringstirred
- filtrationThe resulting solid was collected by filtration
- washThe obtained solid was washed with water and diethyl ether
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-2f3fa683d20e43d580c697040c92e7b9
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09440987B2
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