Diisopropylethylamine → (5-Bromo-pyrimidin-2-yl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amine

온도

100 °C

C-(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-yl)-methylamine (3.47 g) is dissolved in dioxane (50 ml), and thereto are added 5-bromo-2-chloropyrimidine (5.30 g) and N,N-diisopropylethylamine (5.74 ml) and the mixture is stirred at 100° C. for 2 hours and a half. The reaction solution is allowed to cool to room temperature, and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (hexane:ethyl acetate=50:1→22:3) to give (5-bromo-pyrimidin-2-yl)-(5′-isopropyl-2′-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amine (4.82 g). MS (m/z): 482/480 [M+H]+

1. temperatureto cool to room temperature
2. concentrationconcentrated under reduced pressure
3. customThe resulting residue is purified by silica gel column chromatography (hexane:ethyl acetate=50:1→22:3)

ORD 기록

ord-cf3972c6e5ff4c768558029dbd03728c

출처 데이터셋

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07906517B2