Ethyl Acetate → (4-Benzyloxy-5'-isopropyl-2'-methoxy-biphenyl-2-yl)-methanol

HRID 604189노트

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HRID 604189 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:26]=[O:27])[C:12]([C:15]2[CH:20]=[C:19]([CH:21]([CH3:23])[CH3:22])[CH:18]=[CH:17][C:16]=2[O:24][CH3:25])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].[Cl-].[NH4+].C(OCC)(=O)C>C(O)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[C:19]([CH:21]([CH3:22])[CH3:23])[CH:18]=[CH:17][C:16]=2[O:24][CH3:25])=[C:11]([CH2:26][OH:27])[CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 866269194-Benzyloxy-5'-isopropyl-2'-methoxy-biphenyl-2-carbaldehyde

생성물 1

HCID 67087233(4-Benzyloxy-5'-isopropyl-2'-methoxy-biphenyl-2-yl)-methanol수율 108%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Benzyloxy-5′-isopropyl-2′-methoxy-biphenyl-2-carbaldehyde (1.16 g) is dissolved in ethanol (15 ml) and thereto is added sodium borohydride (122 mg) and the mixture is stirred at room temperature for 10 minutes. Thereto are added a saturated aqueous ammonium chloride solution and ethyl acetate, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give (4-benzyloxy-5′-isopropyl-2′-methoxy-biphenyl-2-yl)-methanol (1.26 g). MS (m/z): 345

후처리

  1. customthe mixture is separated
  2. washthe organic layer is washed with a saturated brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-12a5013d06f84f19a62d4febc8ff8916
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07906517B2

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