홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Hydroxide → 1-(3-Methoxy-4-nitro-phenyl)-[4,4']bipiperidine

HRID 604289
노트
인쇄 미리보기

반응식

HRID 604289 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH2:15][CH2:14]1.[OH-].[Na+].[Br-].C([NH3+])CCC>O.C1(C)C=CC=CC=1>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:13]2[CH2:18][CH2:17][CH:16]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[CH2:15][CH2:14]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 14798Sodium HydroxideHCID 7360504,4'-BipiperidineHCID 27792505-Fluoro-2-nitroanisoleHCID 21904131N-butyl-ammonium bromide

생성물 1

HCID 598602801-(3-Methoxy-4-nitro-phenyl)-[4,4']bipiperidine수율 94%

시약·촉매·용매 2

HCID 962Water
용매
HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4-fluoro-2-methoxy-1-nitrobenzene (1.02 g, 5.97 mmol), [4,4′]bipiperidinyl (3.6 g, 14.9 mmol), 2N sodium hydroxide (30 mL), toluene (15 mL) and n-butylammonium bromide (96 mg, 0.30 mmol) is vigorously stirred at 80° C. for 18 hours. After 10 mL of water is added, the mixture is filtrated. The residue is washed with water and then dried to give 1-(3-methoxy-4-nitro-phenyl)-[4,4′]bipiperidine (1.79 g, 94% yield) as yellow solids.

후처리

  1. filtrationthe mixture is filtrated
  2. washThe residue is washed with water
  3. customdried

출처 및 근거

ORD 기록
ord-b836616cf90d4ee690a8c306222371ac
출처 데이터셋
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07910585B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트