Chlorambucil → HCID 178426856, 화합물

HRID 604405

반응식

[CH:1]1[C:6]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=[C:3]([N:13]([CH2:17][CH2:18][Cl:19])[CH2:14][CH2:15][Cl:16])[CH:2]=1.[CH3:20][C:21]1([CH3:31])[N:26]([O:27])[C:25]([CH3:29])([CH3:28])[CH2:24][CH:23]([OH:30])[CH2:22]1>>[CH:5]1[C:6]([CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:1][CH:2]=[C:3]([N:13]([CH2:14][CH2:15][Cl:16])[CH2:17][CH2:18][Cl:19])[CH:4]=1.[CH3:20][C:21]1([CH3:31])[N:26]([O:27])[C:25]([CH3:29])([CH3:28])[CH2:24][CH:23]([OH:30])[CH2:22]1

참가 물질

반응물 2

HCID 2708Chlorambucil

HCID 137994Tempol

생성물 1

HCID 178426856HCID 178426856, 화합물

실험 절차

All the peaks for the product are visible with a slight trace of impurity; proton signal of the reduced nitroxyl radical appears as a broad hump between 8 to 10 ppm. The peaks belonging to the chlorambucil moiety of the adduct are well characterized with the para substituted aromatic protons appearing in the region between 6.5 to 7.03 ppm. The dimethyl groups of TEMPOL appear together as a singlet at 1.3 ppm and the methylene groups at 1.75 -2.07 ppm, the N, N-diethyl chloride peaks in the region between 3.5 and 3.7ppm and the peaks belonging to the butanoic acid chain in the region of 1.75-1.93 and 2.2 -2.5 ppm, as indicated in the following table.

출처 및 근거

ORD 기록: ord-a71ebc9877ef4061a22f971a6868a9c0
출처 데이터셋: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07910607B2

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