Iodine → N-(5-Furan-3-yl-4-phenyl-thiazol-2-yl)-formamide

HRID 604479노트

반응식

HRID 604479 반응식
[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=O)=[CH:2]1.[NH2:15][C:16]([NH2:18])=[S:17].II.[NH4+].[OH-].CN([CH:26]=[O:27])C>O>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[S:17][C:16]([NH:18][CH:26]=[O:27])=[N:15][C:7]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:2]1

참가 물질

7

반응물 5

HCID 807IodineHCID 6228DimethylformamideHCID 14923Ammonium HydroxideHCID 2723790ThioureaHCID 577096042-Furan-3-yl-1-phenyl-ethanone

생성물 1

HCID 57709597N-(5-Furan-3-yl-4-phenyl-thiazol-2-yl)-formamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

To a solution of 2-furan-3-yl-1-phenyl-ethanone (5.7 g, 31 mmol) and thiourea (4.7 g, 61 mmol) in DMF (57 mL) was and added iodine (7.8 g, 31 mmol). The reaction mixture was heated at 100° C. overnight, then it was diluted with water and made alkaline with saturated aqueous NH4OH, and extracted with ether. The organic phases were washed with water, dried over sodium sulfate, concentrated and purified on neutral Al2O3 using 50% ethyl acetate in hexane as eluent. Yield: 5.7 g, 69%.

후처리

  1. extractionextracted with ether
  2. washThe organic phases were washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. custompurified on neutral Al2O3 using 50% ethyl acetate in hexane as eluent

출처 및 근거

ORD 기록
ord-d0bd42ae18bd45618907eeee605def21
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910613B2

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