Pyridine → 2-Bromo-3-oxo-3-phenylpropanenitrile

HRID 604482노트

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HRID 604482 반응식
[O:1]=[C:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][C:4]#[N:5].N1C=CC=CC=1.[Br:18]Br>C(Cl)(Cl)Cl>[Br:18][CH:3]([C:2](=[O:1])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:4]#[N:5]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24408BromineHCID 64799Benzoylacetonitrile

생성물 1

HCID 119615962-Bromo-3-oxo-3-phenylpropanenitrile

시약·촉매·용매 1

HCID 6212Chloroform용매3회

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온도
45 °C

실험 절차

3-Oxo-3-phenylpropionitril (1.5 g, 10 mmol) was dissolved in dry chloroform (10 mL) at 0° C., and pyridine (0.81 mL, 10 mmol) was added. Bromine (4.7 mL, 10 mmol) dissolved in chloroform (4.7 mL) was added dropwise over an hour, then the reaction mixture was heated at 45° C. over night. The reaction mixture was diluted with chloroform and washed with water. The organic phases were dried over sodium sulfate and evaporated to give the crude product, which was used in the next reaction without any further purification.

후처리

  1. additionwas added dropwise over an hour
  2. washwashed with water
  3. dry with materialThe organic phases were dried over sodium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-435832f38ecb4b87994452347d3a1a85
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910613B2

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