Iodine → 2-Amino-4-Phenylthiazole-5-carbonitrile

HRID 604483노트

반응식

HRID 604483 반응식
Br[CH:2]([C:5](=O)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]#[N:4].[NH2:13][C:14]([NH2:16])=[S:15].II.[NH4+].[OH-]>O>[NH2:16][C:14]1[S:15][C:2]([C:3]#[N:4])=[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[N:13]=1

참가 물질

6

반응물 4

HCID 807IodineHCID 14923Ammonium HydroxideHCID 2723790ThioureaHCID 119615962-Bromo-3-oxo-3-phenylpropanenitrile

생성물 1

HCID 214555522-Amino-4-Phenylthiazole-5-carbonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Bromo-3-oxo-3-phenylpropionitrile (0.5 g, 3.4 mmol) was mixed with thiourea (0.52 g, 6.8 mmol) and iodine (0.43 g, 3.4 mmol) and the mixture was heated on a steam bath for 12 h. It was then diluted with water and made alkaline with saturated aqueous NH4OH, and extracted with ethyl acetate. The organic phases were washed with water and brine, dried over sodium sulfate, and evaporated to dryness to give the crude product, which was used in the next reaction without any further purification. Yield: 0.2 g, 29%.

후처리

  1. temperaturethe mixture was heated on a steam bath for 12 h
  2. extractionextracted with ethyl acetate
  3. washThe organic phases were washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-03d78c88d23b42f9abb204f8b42379f8
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910613B2

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