Water → 2-amino-4-phenyl-1,3-thiazole-5-carbohydrazide

HRID 604491노트

반응식

HRID 604491 반응식
C([O:3][C:4]([C:6]1[S:10][C:9]([NH2:11])=[N:8][C:7]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)C.O.[NH2:19][NH2:20].O>CO>[NH2:11][C:9]1[S:10][C:6]([C:4]([NH:19][NH2:20])=[O:3])=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)2회HCID 73239Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 14819492-amino-4-phenyl-1,3-thiazole-5-carbohydrazide수율 70%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Amino-4-phenyl-thiazole-5-carboxylic acid ethyl ester (5.0 g, 20 mmol) was suspended in methanol. Hydrazine monohydrate (5 mL, 100 mmol) was added and heated to reflux for 2 h. Hydrazine monohydrate (10 mL) was added and heated to reflux for 48 h. Water (100 mL) was added to the reaction mixture and the methanol was removed by evaporation in vacuo. The product precipitates and the solid product is collected by filtration. Yield: 70%.

후처리

  1. temperatureheated
  2. temperatureto reflux for 2 h
  3. temperatureheated
  4. temperatureto reflux for 48 h
  5. customthe methanol was removed by evaporation in vacuo
  6. customThe product precipitates
  7. filtrationthe solid product is collected by filtration

출처 및 근거

ORD 기록
ord-0bd77e4e343e477e91ed3a528e4aeb3c
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910613B2

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