4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 604697노트

반응식

HRID 604697 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

생성물 1

HCID 45247074-BROMO-4'-SULFOBIPHENYL수율 92%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A 500 mL round-bottom-flask equipped with an addition funnel, stirring bar, and gas inlet was charged with 4-bromo-biphenyl (50 g, 0.215 mol) and chloroform (200 mL) then purged with nitrogen. Chlorosulfonic acid (18 mL, 0.27 mol) was added dropwise to the solution from the addition funnel then stirred for 1 hour. The resulting precipitate was collected by vacuum filtration, washed with cold chloroform, and dried under vacuum to give 61.97 g of 4′-bromo-biphenyl-4-sulfonic acid (92% yield).

후처리

  1. customA 500 mL round-bottom-flask equipped with an addition funnel
  2. customthen purged with nitrogen
  3. stirringthen stirred for 1 hour
  4. filtrationThe resulting precipitate was collected by vacuum filtration
  5. washwashed with cold chloroform
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-8e8a19e18e314e7689fa1daf4f9bae08
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910653B2

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