Dimethylformamide → 3-Dimethylaminobenzoyl chloride hydrochloride
반응식
[CH3:1][N:2]([CH3:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](O)=[O:7].C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>ClC(Cl)C>[ClH:16].[CH3:1][N:2]([CH3:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([Cl:16])=[O:7]참가 물질
5
실험 절차
To a solution of 3-(dimethylamino) benzoic acid (5.0 g. 30.0 mmol) in dichloroethane (50 mL) was added oxalyl chloride (5.6 g, 44.6 mmol) drop wise followed by catalytic amount of DMF. The reaction was stirred for 16 h. The excess oxalyl chloride and solvent were removed under reduced pressure. The residue was chased with benzene to give the desired product (6.1 g, 92%).
후처리
- customThe excess oxalyl chloride and solvent were removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-5d75a835a4854f5189d6479b84c00620
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07910595B2
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