Benzoyl chloride → N-(5-chloro-2-methyl-4-nitrophenyl)benzamide

HRID 605292노트

반응식

HRID 605292 반응식
[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([CH3:9])=[C:6]([NH2:8])[CH:7]=1.[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([CH3:9])=[C:6]([NH:8][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1

참가 물질

4

반응물 2

HCID 7412Benzoyl chlorideHCID 837726-Chloro-4-nitro-o-toluidine

생성물 1

HCID 4158578N-(5-chloro-2-methyl-4-nitrophenyl)benzamide수율 32%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 5-chloro-2-methyl-4-nitrophenylamine (0.560 g, 3.00 mmol) and benzoyl chloride (0.422 g, 3.00 mmol) in toluene (15 mL) was heated under reflux for 1.5 h, and cooled to room temperature. A solid crystallized from the reaction mixture upon cooling, and was isolated by vacuum filtration and dried to provide the title compound as a gray solid (0.276 g, 32%).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 h
  3. customA solid crystallized from the reaction mixture
  4. temperatureupon cooling
  5. customwas isolated by vacuum filtration
  6. customdried

출처 및 근거

ORD 기록
ord-ddf67a31fca7406ab29e0738bd32721d
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07910595B2

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