Hydrochloric Acid → Benzyl piperidine-4-carboxylate hydrochloride
반응식
[CH2:1]([O:8][C:9]([CH:11]1[CH2:16][CH2:15][N:14](NC(OC(C)(C)C)=O)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:25]>O1CCOCC1>[ClH:25].[CH2:1]([O:8][C:9]([CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
4
실험 절차
1-[(1,1-Dimethylethoxycarbonyl)amino]-piperidine-4-carboxylic acid benzyl ester (7 g, 21.0 mmol), from step 2, was dissolved in 1,4-dioxane (20 ml). To this solution, HCl 4N in 1,4-dioxane (7.8 ml, 300 ml, 12 eq.) was added and the resulting solution was stirred overnight at room temperature. The solid was filtered, suspended in n-hexane (50 ml), and filtered to give a white solid. Yield 54%, 2.5 g.
후처리
- filtrationThe solid was filtered
- filtrationfiltered
- customto give a white solid
출처 및 근거
- ORD 기록
- ord-600a9f87976746e88ecec8b3e7d7e8fa
- 출처 데이터셋
- uspto-grants-2011_03
- 특허 번호
- US07915236B2
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