Hydrochloric Acid → 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

HRID 60571

반응식

HRID 60571 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86680841Methyl 5-methyl-2-(pyridin-4-yl)benzoate

생성물 1

HCID 866808425-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of methyl 5-methyl-2-(pyridin-4-yl)benzoate (8.8 g), 6 N hydrochloric acid (65 mL) and acetic acid (100 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained solid was washed with ethyl acetate to give the title compound (6.6 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained solid was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-af2844a64cfa403e89abd8269f3bd4d6
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440990B2

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