Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride

HRID 60584노트

반응식

HRID 60584 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86680852Methyl 2-(pyrimidin-4-yl)benzoate

생성물 1

HCID 866808532-(Pyrimidin-4-yl)benzoic acid hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-64ad8669fdd7422f8bff69f46dec81c0
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440990B2

반응 노트

불러오는 중…