1-Propanol → 5-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-2-morpholin-4-yl-benzamide

HRID 605907

반응식

HRID 605907 반응식
CN1CC[N:5]([C:8]2[CH:13]=C[C:11]([NH:14][C:15]3[C:16]4N(N=CN=4)C(C4C=C(C(N)=O)SC=4)=CN=3)=[CH:10][CH:9]=2)CC1.[Br:32][C:33]1[N:38]2[N:39]=[CH:40][N:41]=[C:37]2[C:36](Br)=[N:35][CH:34]=1.C([N:46](CC)C(C)C)(C)C.[CH2:52]([OH:55])[CH2:53]C.C[CH:57]([OH:59])[CH3:58]>CCOCC>[Br:32][C:33]1[N:38]2[N:39]=[CH:40][N:41]=[C:37]2[C:36]([NH:5][C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:15][CH2:16][O:55][CH2:52][CH2:53]3)=[C:58]([CH:13]=2)[C:57]([NH2:46])=[O:59])=[N:35][CH:34]=1

참가 물질

7

반응물 5

HCID 10311-PropanolHCID 3776IsopropanolHCID 81531DiisopropylethylamineHCID 497580225,8-Dibromo-(1,2,4)triazolo(1,5-a)pyrazineHCID 575899284-{8-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-thiophene-2-carboxylic acid amide

생성물 1

HCID 575900535-(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-2-morpholin-4-yl-benzamide수율 73%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

This compound may be prepared using methods as described for Compound 6, step 1 using 5,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (250 mg, 0.90 mmol) 5-amino-2-morpholin-4-yl benzamide (299 mg, 1.35 mmol) and N,N-diisopropylethylamine (0.24 mL, 1.35 mmol) in 2-propanol (7 mL). Trituration with PrOH and Et2O affords the title compound (273 mg, 73%).

후처리

  1. customThis compound may be prepared

출처 및 근거

ORD 기록
ord-107f71fcc5fa4c66a874357fe4a3f499
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915256B2

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