Water → 2-(5-Oxazolyl)benzoic Acid

HRID 60601노트

반응식

HRID 60601 반응식
[O:1]1[C:5]([C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[C:8]([O:10]C)=[O:9])=[CH:4][N:3]=[CH:2]1.[OH-].[Na+].O>C1COCC1>[O:1]1[C:5]([C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[C:8]([OH:10])=[O:9])=[CH:4][N:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 73553912Methyl 2-(5-Oxazolyl)benzoate

생성물 1

HCID 533937912-(5-Oxazolyl)benzoic Acid수율 88.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 2-(1,3-oxazol-5-yl)benzoate (4.0 g) in THF (40 mL) was added 2 N aqueous sodium hydroxide solution (20 mL), and the mixture was stirred at room temperature stirred for 2 days. To the reaction mixture was added water, and the mixture was washed with tert-butyl methyl ether. The pH of the obtained aqueous layer was adjusted to 2 with 2N hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate/petroleum ether to give the title compound (3.3 g)

후처리

  1. stirringstirred for 2 days
  2. washthe mixture was washed with tert-butyl methyl ether
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure
  7. washThe residue was washed with ethyl acetate/petroleum ether

출처 및 근거

ORD 기록
ord-61a20306c40c42c3b32fb9f85b8946b1
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440990B2

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