Water → Phthalylglycine aldehyde

HRID 606122

반응식

HRID 606122 반응식
O.FC(F)(F)C(O)=O.C([O:11][CH:12](OCC)[CH2:13][N:14]1[C:18](=[O:19])[C:17]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]2[C:15]1=[O:24])C>C(Cl)(Cl)Cl>[O:24]=[C:15]1[C:16]2[C:17](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18](=[O:19])[N:14]1[CH2:13][CH:12]=[O:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 3152862-Phthalimidoacetaldehyde Diethyl Acetal

생성물 1

HCID 76201Phthalylglycine aldehyde수율 65.8%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Water (50 mL) and trifluoroacetic acid (50 mL) were added to a solution of phthalimidoacetaldehyde diethyl acetal (30.0 g, 114 mmol) in chloroform (200 mL), and the reaction mixture was stirred at room temperature for 48 hours. The aqueous layer was separated, adjusted to pH 7 with the addition of sodium carbonate, and extracted with several portions of dichloromethane. The combined organic fractions were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to provide 14.2 g of (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetaldehyde as a white solid.

후처리

  1. customThe aqueous layer was separated
  2. additionadjusted to pH 7 with the addition of sodium carbonate
  3. extractionextracted with several portions of dichloromethane
  4. dry with materialThe combined organic fractions were dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7ef28f501bb744008f701a1198c8f3c7
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915281B2

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