4-(Phenoxymethyl)piperidine → 2-Tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine

HRID 606240

반응식

HRID 606240 반응식
[C:1]([O:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH:12]=[CH2:13])[N:7]=1)([CH3:4])([CH3:3])[CH3:2].[O:14]([CH2:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[C:1]([O:5][C:6]1[CH:11]=[N:10][CH:9]=[C:8]([CH2:12][CH2:13][N:25]2[CH2:26][CH2:27][CH:22]([CH2:21][O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:23][CH2:24]2)[N:7]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 30174444-(Phenoxymethyl)piperidineHCID 222482762-Tert-butoxy-6-vinylpyrazine

생성물 1

HCID 222485282-Tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

After dissolving 471 mg of 2-tert-butoxy-6-vinylpyrazine and 505 mg of 4-(phenoxymethyl)piperidine in 10 ml of ethanol, the mixture was stirred for 4 days at 80° C. The reaction solution was concentrated under reduced pressure and the residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain 2-tert-butoxy-6-[2-(4-phenoxymethylpiperidino)ethyl]pyrazine.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was purified by NH silica gel column chromatography (solvent: n-hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-9e16f06448fc4f8fb6369ece4d7ea4d2
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07915274B2

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